Could You Be Suffering From Endocannabinoid Deficiency?

Could You Be Suffering From Endocannabinoid Deficiency?

Researchers believe that a disorder known as clinical endocannabinoid deficiency could be the root cause of many people suffering from medical conditions.

It is a recurring theory that there may be a clinical endocannabinoid deficiency (CECD) behind several different disorders, especially those related to the immune system and inflammation. In past articles, we discussed the purpose of the endocannabinoid system briefly.

The endocannabinoid system consists of lipid-based neurotransmitters, called endocannabinoids, which work together to regulate various body processes and create a physiological equilibrium state. Managing pain, cognition, memory, mood, sleep, immune response, and appetite are some of its primary functions.

What is Endocannabinoid Deficiency?

Endocannabinoid Deficiency happens when the body does not produce enough cannabinoids or receptors that affect many different functions of the body, as stated above. As a result, the body becomes unbalanced, which can eventually lead to diseases and disorders.

According to the well - known cannabinoid researcher Dr Ethan Russo, people diagnosed with a clinical endocannabinoid deficiency can significantly benefit from supplementing with plant-based phytocannabinoids – cannabinoids.

What Conditions Result from Endocannabinoid Deficiency?

“Migraine, fibromyalgia, irritable bowel syndrome and related conditions display common clinical, biochemical and pathophysiological patterns that suggest a clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines,” Russo commented on it in his study of 2004. Over the years, in 2014 and 2016, this research has been reviewed a few times.

However, there is a comprehensive list of CECD - related disorders such as neonatal failure to thrive, cystic fibrosis, causalgia, brachial plexopathy, phantom limb pain, childhood colic, glaucoma, dysmenorrhea, hyperemesis gravidarum, unexplained repetitive miscarriages, post-traumatic stress disorder, bipolar disease, etc.

Besides, since endocannabinoids have also been linked to neurological disorders, it makes sense that the underlying cause of diseases such as Alzheimer's and Parkinson's could also be a deficiency. This could be why when self-medicating with cannabis products, people suffering from these conditions report success.

How is it Diagnosed?

The science has evolved tremendously since the discovery of the endocannabinoid system in the early 1990s. Old endocannabinoid measurement methods were complex and invasive. Most often, cutting into the brain, collecting lipids, and analysing them with chromatography of liquid or gas was done.

The tactics became less invasive over time, and microdialysis was a standard procedure for checking endocannabinoid levels. The techniques have evolved even further these days, enabling healthcare professionals to measure endocannabinoids in the saliva or plasma of a patient.

While there is a need for more research before official treatment plans can be implemented, this could pave the way for new and natural methods to treat certain conditions.